Industry Disruptors

THC / CBD compounds are:

  • Only 4% – 20% bio-available when ingested 1
  • On-set usually takes between 90 – 120 minutes
  • Largely destroyed by stomach acid
  • Bad tasting upon oral intake
  • Unable to significantly cross intestinal wall or blood-brain barrier
  • Broken down by the liver, loosing efficacy

Cryopharm Technology Enables:

  • On-set in as little as 12 minutes
  • 94% Sublingual absorption
  • Flavor masking for poor tasting compounds.
  • 6 – 7x more efficient that ingestible edibles such as THC/CBD
  • 84% cheaper to manufacture (less active ingredients needed to achieve desired results)

Buccal & Sublingual Absorption

Buccal & Sublingual administration is a topical route of administration by which drugs held or applied in the buccal (/ˈbʌkəl/) area (in the cheek) diffuse through the oral mucosa (tissues which line the mouth) and enter directly into the bloodstream.

The patented proprietary Cryopharm processes dramatically enhances sublingual absorption thus lowering response times in the body by bypassing hepatic metabolism.1

The bioavailability of swallowing THC & CBD has been proven to be low — ranging from 4% to 20% with most results in the lower range. This is attributed to “first-pass metabolism”. 2

Cryopharm’s Sublingual Emulsifying Nano Drug Delivery system (SEND) for both THC and CBD demonstrated bioavailability levels (116% and 131% for CBD and THC, respectively). 2

1 Journal of Pharmaceutical Research Volume 16, Issue 3, Jul-Sep. 2017

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